Talks

The vast majority (~98%) of the mammalian genome is noncoding but has a vital role in gene regulation. Enhancers are noncoding DNA sequences highly enriched in binding sites for tissue-specific transcription factors. Genes with pleiotropic roles in development often have huge regulatory landscapes (~ 1Mb) with multiple enhancers driving precise gene expression.
The human genome is thought to contain 100s of thousands of enhancers with, as yet, uncharacterised activities and a large proportion of disease-causing and disease-predisposing DNA sequence variants map to potential enhancers. To advance understanding of human disease, massive efforts are currently being directed towards establishing genotype to phenotype correlations for sequence variants. A key pre-requisite to these analyses is defining the precise cell- and tissue-specific activities of the enhancers and the transcription factors that bind them.
Our research focuses on building models for understanding cell-type specific ...

This work investigates the ferroelectric properties of γ − In₂Se₃, a material that uniquely retains its spontaneous polarization at the nano-scale, making it resistant to depolarizing fields. With a direct band gap of 1.8 eV and the ability to switch between insulating and semiconducting phases at room temperature, γ − In₂Se₃ holds promise for next-gen memory devices, where its stable ferroelectricity could revolutionize data storage and processing.

The black hole information paradox is a fundamental conflict between the quantum-mechanical and thermodynamic descriptions of black holes, specifically of their particle-emission process known as the Hawking radiation. The paradox concerns whether the radiation of a black hole is a unitary time evolution or a thermal process that erases most information about the initial state of the black hole. Multiple black hole models (e.g. [1,2]) were shown to exhibit the Page curve behavior, suggesting the unitarity of the Hawking radiation. However, without a verified theory of quantum gravity, the exact structure of black holes remains undetermined, and we need a model-independent way to test black hole unitarity. My project thus aims to develop a general framework for testing black hole unitarity by searching for its physical signatures. In particular, we employ the "hybrid" RST model [3], which possesses a Page-curve behavior, and study whether the unitarity is manifested in the transition rate of the Unruh-DeWitt particle detector. [1] Hong Zhe Chen, Robert C. Myers, Dominik Neuenfeld, Ignacio A. Reyes, Joshua Sandor. Quantum Extremal Islands Made Easy, Part II: Black Holes on the Brane". https://doi.org/10.48550/arXiv.2010.00018. [2] Yohan Potaux, Sergey N. Solodukhin, and Debajyoti Sarkar. "Spacetime Structure, Asymptotic Radiation, and Information Recovery for a Quantum Hybrid State.” Physical Review Letters 130, no. 26 (June 30, 2023): 261501. https://doi.org/10.1103/PhysRevLett.130.261501. [3] Yohan Potaux, Debajyoti Sarkar, and Sergey N. Solodukhin. "Quantum States and Their Back-Reacted Geometries in 2D Dilaton Gravity.” Physical Review D 105, no. 2 (January 12, 2022): 025015. https://doi.org/10.1103/PhysRevD.105.025015.

It may be the case that a spacetime exhibits no asymptotia where gauge invariant observables can be defined in a natural way. On such occasions the introduction of a timeline boundary may be helpful. We therefore discuss the initial boundary value problem in the context of General Relativity.

The theory $S = \int\text{d}^{4-\epsilon}x\left(\frac{1}{2}|\partial\phi|^2 - \frac{m^2}{2}|\phi|^2-\frac{g}{16}|\phi|^4\right)$ exhibits a global $U(1)$ symmetry, and the operators $\phi^n$ ($\bar\phi^n$) have charge $n$ ($-n$) with respect to this symmetry. By rescaling the fields and the coupling constant, it is possible to work in a double limit $n\to\infty$, $g\to 0$ with $\lambda = gn$ kept constant. In this way, it is possible to compute 2-point functions of the form $\langle \phi^n(x) \bar\phi^n(0) \rangle$ in the large $n$ limit, either diagrammatically by a resummation of the leading contribution at all orders in $g$, or using semiclassical methods through the saddle point approximation. This second approach is particularly powerful because it can also be applied to the theory on a curved background. This allows obtaining the form of the 2-point function for an arbitrary metric, and by functionally differentiating with respect to it, it is also possible to obtain, in the flat theory, the 3-point function $\langle T^{ij}(z) \phi^n(x) \bar \phi^n(0) \rangle$ in which an energy-momentum tensor has been inserted. This allows for a non-trivial check of the conformal symmetry of this sector of the theory by verifying the Ward identities that this 3-point function should satisfy.

We discuss the concept of spontaneous symmetry breaking and illustrate it with a general example. We consider Wigner-Weyl and Nambu-Goldstone realisations of symmetry in the quantum theory. Next, we state Goldstone’s theorem and sketch its proof. We discuss why quantum chromodynamics is not realised in the Wigner-Weyl mode.

There are now multiple direct probes of the region near black hole horizons, including direct imaging with the Event Horizon Telescope (EHT). As a result, it is now of considerable interest to identify what aspects of the underlying spacetime are constrained by these observations. For this purpose, we present a new formulation of an existing broad class of integrable, axisymmetric, stationary spinning black hole spacetimes, specified by four free radial functions, that makes manifest which functions are responsible for setting the location and morphology of the event horizon and ergosphere. We explore the size of the black hole shadow and high-order photon rings for polar observers, approximately appropriate for the EHT observations of M87*, finding analogous expressions to those for general spherical spacetimes. Of particular interest, we find that these are independent of the properties of the ergosphere, but does directly probe on the free function that defines the event horizon. Based on these, we extend the nonperturbative, nonparametric characterization of the gravitational implications of various near-horizon measurements to spinning spacetimes. Finally, we demonstrate this characterization for a handful of explicit alternative spacetimes.

In this work, we propose a systematic method to obtain the effective field theory of the quantum dissipative systems which nonlinearly realize symmetries. We focus on the high temperature or Brownian limit, in which the effective action of the dissipative dynamics is localized in time. We first introduce a microscopic model at the linear response level, which shows how the dissipative dynamics on Lie group emerges effectively through the reduced dynamics of a system interacting with a thermal bath. The model gives a systematic method to give the Langevin equation which is covariant with respect to the symmetries of the system. In addition, the model shows a systematic way to go beyond the Gaussian white noise and the interaction between the noise and dissipation. Then, using the dynamical KMS symmetry, without any reference to the microscopic structure of the bath, we obtain the most general effective action of the nonlinearly realized dissipative dynamics at high temperature. The universal dissipative coefficients are larger than the case of the linear response approximation. Then, we focus on the case of Ohmic friction where the corresponding dissipative coefficients are more restricted; we suggest an alternative model, the bulk model, to describe any Ohmic dissipative system at high temperature. The Bulk model provides a geometrical picture for the noise in the case of Ohmic friction.

This talk will be based on SciPost Phys. 17, 021 (2024). Defects are common in physical systems with boundaries, impurities or extensive measurements. The interaction between bulk and defect can lead to rich physical phenomena. Defects in gapless phases of matter with conformal symmetry usually flow to a defect conformal field theory (dCFT). Understanding the universal properties of dCFTs is a challenging task. In this talk, we propose a computational strategy applicable to a line defect in arbitrary dimensions. Our main assumption is that the defect has a UV description in terms of a local modification of the Hamiltonian so that we can compute the overlap between low-energy eigenstates of a system with or without the defect insertion. We argue that these overlaps contain a wealth of conformal data, including the $g$-function, which is an RG monotonic quantity that distinguishes different dCFTs, the scaling dimensions of defect creation operators $\Delta^{+0}_\alpha$ and changing operators $\Delta^{+-}_\alpha$ that live on the intersection of different types of line defects, and various OPE coefficients. We apply this method to the fuzzy sphere regularization of 3D CFTs and study the magnetic line defect of the 3D Ising CFT. Using exact diagonalization and DMRG, we report the non-perturbative results $g=0.602(2),\Delta^{+0}_0=0.108(5)$ and $\Delta^{+-}_0=0.84(5)$ for the first time. We also obtain other OPE coefficients and scaling dimensions. Our results have significant physical implications. For example, they constrain the possible occurrence of spontaneous symmetry breaking at line defects of the 3D Ising CFT. Our method can be potentially applied to various other dCFTs, such as plane defects and Wilson lines in gauge theories.

As part of a monthly webinar series jointly hosted by Perimeter, IVADO, and Institut Courtois, Ilya Shpitser will present an introduction to causal inference and its applications to problems in physics and computer science. This seminar will be fully on zoom and members of all three institutes are welcome. 

Abstract: In this talk I will give some history of ideas of causal inference, describe the causal inference workflow, including formalizing the cause-effect question in terms of a parameter, defining (or learning) the causal model, checking if the data has information about the desired parameter via identification theory, and efficiently estimating the parameter if it is identified.  I will briefly touch on connections of causal inference to other areas, discuss what machine learning and causal inference can teach each other, and describe some open problems.   Zoom TBC