Public Lecture Series

Imagine going beyond treating the symptoms of disease and instead stopping it and reversing it. This is the promise of regenerative medicine.

In her Perimeter Institute public lecture, Prof. Molly Shoichet will tell three compelling stories that are relevant to cancer, blindness and stroke. In each story, the underlying innovation in chemistry, engineering, and biology will be highlighted with the opportunities that lay ahead. 

To make it personal, Shoichet’s lab has figured out how to grow cells in an environment that mimics that of the native environment. Now she has the opportunity to grow a patient’s cancer cells in the lab and figure out which drugs will be most effective for that individual. 

In blindness, the cells at the back of the eye often die. We can slow the progression of disease but we cannot stop it because there is no way to replace those cells. With a newly engineered biomaterial, Shoichet’s lab can now transplant cells to the back of the eye and achieve some functional repair. 

The holy grail of regenerative medicine is stimulation of the stem cells resident in us. The challenge is to figure out how to stimulate those cells to promote repair. Using a drug-infused “band-aid” applied directly on the brain, Shoichet’s team achieved tissue repair. 

These three stories underline the opportunity of collaborative, multi-disciplinary research. It is exciting to think what we will discover as this research continues to unfold.

When small, hard particles are suspended in a fluid, they make it more resistant to flow. The higher the particle concentration, the higher the viscosity. Add enough particles and fluid stops flowing entirely, becoming a jammed solid - this makes intuitive sense.

Less intuitive and more intriguing are suspensions that flow smoothly if pushed gently, but that suddenly solidify if you push too hard. This behaviour is called Discontinuous Shear Thickening (DST). You can try it yourself by mixing cornstarch with water - in the right proportions, the mixture will flow smoothly when stirred gently, but will refuse to flow at all if stirred too hard.

More than an interesting kitchen trick, DST has important real-world consequences. It can cause catastrophic failure of industrial pumping equipment, but can also have life-saving applications to bulletproof vests.

For many years, the mechanism behind DST was unclear, but we have very recently found a new and stunningly simple explanation based on the idea that the contacts between particles become less lubricated and more frictional as the force between them increases. Although this dependence is typically gradual, when a fluid gets close to the “jamming” point, global instabilities can result in the sudden switching from liquid to solid.

Michael Cates (Lucasian Professor of Mathematics, University of Cambridge) will explain this peculiar form of “bulletproof custard” with a few equations, plenty of diagrams, and even some hands-on demonstrations.

Even the greatest scientists have made some serious blunders. "Brilliant Blunders" concerns the evolution of life on Earth, of the Earth itself, of stars, and of the universe as a whole.

In this talk, astrophysicist Dr. Mario Livio will explore and analyze major errors committed by such luminaries as Charles Darwin, Linus Pauling, and Albert Einstein. Dr. Livio will scrutinize the various types of blunders and attempt to explain how they happen. Blunders are not only inevitable, argues Dr. Livio, but also an integral component of the process of science.

How well can we predict our future climate? If the flap of a butterfly’s wings can change the course of weather a week or so from now, what hope trying to predict anything about our climate a hundred years hence? In this talk I will discuss the science of climate change from a perspective which emphasises the chaotic (and hence uncertain) nature of our climate system. In so doing I will outline the fundamentals of climate modelling, and discuss the emerging concept of inexact supercomputing, needed - paradoxically perhaps - if we are to increase the accuracy of predictions from these models. Indeed, revising the notion of a supercomputer from its traditional role as a fast but precise deterministic calculating machine, may be important not only for climate prediction, but also for other areas of science such as astrophysics, cosmology and neuroscience.

By creating an ultra-clean underground location with a highly reduced radioactive background, otherwise impossible measurements can be performed to study fundamental physics, astrophysics and cosmology. The Sudbury Neutrino Observatory (SNO) was a 1,000 tonne heavy-water-based neutrino detector created 2 km underground in a mine near Sudbury, Canada. SNO has used neutrinos from 8B decay in the Sun to observe one neutrino reaction sensitive only to solar electron neutrinos and others sensitive to all active neutrino flavors. It found clear evidence for neutrino flavor change that also requires that neutrinos have non-zero mass. This requires modification of the Standard Model for Elementary Particles and confirms solar model calculations with great accuracy. The 2015 Nobel Prize in Physics and the 2016 Breakthrough Prize in Fundamental Physics were awarded for these measurements. Future measurements at the expanded SNOLAB facility will search for Dark Matter particles thought to make up 26% of our Universe and rare forms of radioactivity that can tell us further fundamental properties of neutrinos potentially related to the origin of our matter-dominated Universe.

The ordinary atoms that make up the known universe, from our bodies and the air we breathe to the planets and stars, constitute only 5 percent of all matter and energy in the cosmos. The remaining 95 percent is a recipe of 25 percent dark matter and 70 percent dark energy, both nonluminous components whose nature remains a mystery.

In her March 2 public lecture, Katherine Freese will recount the hunt for dark matter, from the discoveries of visionary scientists like Fritz Zwicky, the Swiss astronomer who coined the term "dark matter" in 1933, to the deluge of data today from underground laboratories, satellites in space, and the Large Hadron Collider.

Neutron stars are a celestial gift to scientists. These incredibly dense collapsed stars act as very precise cosmic beacons that help shed light on some of the most challenging problems in modern physics.

In her Feb. 3 talk at Perimeter Institute, astrophysicist Victoria Kaspi will explore these strange objects, explain how astronomers are using them to study issues ranging from the origins of the universe to the very nature of matter, and even let the audience hear the cosmic symphony they create.

Emerging techniques and technologies, drawn from many fields of science and medicine, are allowing us to peer inside the human body with unprecedented sensitivity and to probe the fundamental processes of life – in real time. TRIUMF’s Life Sciences Division is making such studies possible with isotopes, short-lived elements that are harnessed and incorporated into next generation pharmaceuticals designed to provide incredible insight into the complex systems that make up life. With its specialized expertise and facilities in particle accelerator targets, isotope production, and radiochemistry, TRIUMF – Canada’s national laboratory for particle and nuclear physics and accelerator-based science – has unique capabilities in this area.

In his talk, Dr. Paul Schaffer, Associate Laboratory Director of TRIUMF’s Life Sciences Division, will explore how he and his team use accelerators to develop tools and techniques to advance the field of nuclear medicine. He’ll share leading-edge developments and discuss the promise advanced medical isotopes hold for disease diagnostics and therapeutics, as well as talk about his team’s award-winning efforts to produce a secure supply of critical medical isotopes.

Atomic clocks are the most precise timekeepers ever built. If you could keep an advanced atomic clock running long enough, it would neither gain nor lose a single second over the entire lifespan of the universe. With the availability of spectrally pure lasers and the ability to precisely measure optical frequencies, it appears the era of optical atomic clocks has begun. Advances in atomic clocks are expected to be important in a range of emerging technological applications, including quantum computers. Dr. David Wineland, 2012 Nobel Laureate in Physics, will explore the theoretical and technological know-how needed to build these ultra-precise timepieces during his Perimeter Institute Public Lecture on Wednesday, Nov. 4. 

Fundamental physics has reached a turning point. The most powerful experiments ever devised are revealing the structure of the universe with unprecedented clarity. On the largest scales – the whole visible universe – and the tiniest, we are discovering remarkable simplicity, which our theories do not yet explain. In between, things are complex. But here too, new technologies are allowing us to access the quantum frontier, opening up new high-precision probes of the fundamental laws of nature and revolutionary new technologies. We stand on the threshold of breakthroughs, both theoretical and experimental, which could change our picture of the world and the development of our society.

Niels Bohr was Nobel-winning physicist – a pioneer of quantum theory – but his influence extended far beyond his own research. He was a gifted teacher who established one of the 20th century’s most important centres for physics, and was instrumental in the development of physics worldwide. He became a statesman following the Second World War, calling for international cooperation to avoid nuclear conflict. Bohr’s legacy – in science, humanitarianism, and family – spans generations, as his grandson will illustrate during a special public lecture webcast at Perimeter Institute. Dr. Vilhelm Bohr, a researcher at the National Institute on Aging in Maryland and Chairman of the Niels Bohr Archive in Copenhagen, will provide unique insights into his grandfather’s multifaceted personality, as well as the important influence of Niels Bohr’s father, wife, and brother.