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Models with right-handed currents have recently attracted attention because of their potential ability to solve the discrepancy in various determinations of |V_{ub}|. We consider a minimal setup with an SU(2)_L x SU(2)_R x U(1)_{B-L} gauge symmetry, for which we perform a simultaneous analysis of the most important constraints from electroweak precision observables, particle anti-particle mixing and the B -> X_{s,d} gamma decays. The main goals of our analysis are the determination of allowed parameter space for the new right-handed mixing matrix and the possible solution of various anomalies in the current flavor data.