ICTS:32810

small RNA-mediated epigenetic regulation of pathogenesis and host-parasite interaction

(2025). small RNA-mediated epigenetic regulation of pathogenesis and host-parasite interaction. SciVideos. https://scivideos.org/index.php/icts-tifr/32810

small RNA-mediated epigenetic regulation of pathogenesis and host-parasite interaction. SciVideos, Oct. 03, 2025, https://scivideos.org/index.php/icts-tifr/32810 

          @misc{ scivideos_ICTS:32810,
            doi = {},
            url = {https://scivideos.org/index.php/icts-tifr/32810},
            author = {},
            keywords = {},
            language = {en},
            title = {small RNA-mediated epigenetic regulation of pathogenesis and host-parasite interaction},
            publisher = {},
            year = {2025},
            month = {oct},
            note = {ICTS:32810 see, \url{https://scivideos.org/index.php/icts-tifr/32810}}
          }
Meetali Singh
Talk numberICTS:32810
Source RepositoryICTS-TIFR

Abstract

small RNAs are among the main drivers of epigenetic gene regulation. There are three main categories of small RNAs: microRNAs, piRNAs, and endogenous siRNAs. These various small RNA pathways are conserved across most eukaryotes. I will talk about the role of small RNAs in the inheritance of memory of stress using the nematode model, followed by our findings on the role of microRNAs in host-pathogen interaction using the SARS-CoV-2 model. We sequenced small RNAs from SARS-CoV-2-infected cells and identified a miRNA derived from a recently evolved region of the viral genome that targets the 3′UTR of interferon-stimulated genes and represses their expression, thus aiding in host immune evasion. Lastly, I will highlight our group’s new ventures to understand the role of small RNAs in host-parasite interaction using the eukaryotic parasite Toxoplasma as a model.