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There is a well-known discrepancy in mathematical fluid mechanics between phenomena that we can observe and phenomena on which we have theorems. The challenge for the mathematician is then to formulate an existence theory of solutions to the equations of hydrodynamics which is able to reflect observation. The most important such observation, forming the backbone of turbulence theory, is anomalous dissipation. In the talk, we survey some of the recent developments concerning weak solutions in this context.

In the recent resolution of the strong Onsager’s conjecture in L^3 framework, so-called wavelet-inspired Nash’s iteration has been developed. In this lecture, we will sketch this new method and provide the necessary background. The lecture will be based on our recent joint work with Matthew Novack.

We say that an ordinary or partial differential equation is regularized by noise if the addition of a suitable noise term restores well-posedness or improves regularity of the solution to the equation. Regularization by noise is by now well understood for ODEs and linear transport-type PDEs, but it is less understood for nonlinear PDEs like Euler and Navier-Stokes equations, with many open questions.

In the first part of this series of lectures, we consider the case of ODEs and associated transport equations with irregular drift: we show that the addition of an additive Brownian noise restores well-posedness of the ODE; we introduce the corresponding transport noise and show that this noise restores well-posedness for the associated transport equation. In the second part, we focus our attention on the effect of a particular transport-type noise, which is divergence-free, Gaussian, white in time and poorly correlated in space (nonsmooth Kraichnan noise). The associated linear transpo...

There is a well-known discrepancy in mathematical fluid mechanics between phenomena that we can observe and phenomena on which we have theorems. The challenge for the mathematician is then to formulate an existence theory of solutions to the equations of hydrodynamics which is able to reflect observation. The most important such observation, forming the backbone of turbulence theory, is anomalous dissipation. In the talk, we survey some of the recent developments concerning weak solutions in this context.

We say that an ordinary or partial differential equation is regularized by noise if the addition of a suitable noise term restores well-posedness or improves regularity of the solution to the equation. Regularization by noise is by now well understood for ODEs and linear transport-type PDEs, but it is less understood for nonlinear PDEs like Euler and Navier-Stokes equations, with many open questions.

In the first part of this series of lectures, we consider the case of ODEs and associated transport equations with irregular drift: we show that the addition of an additive Brownian noise restores well-posedness of the ODE; we introduce the corresponding transport noise and show that this noise restores well-posedness for the associated transport equation. In the second part, we focus our attention on the effect of a particular transport-type noise, which is divergence-free, Gaussian, white in time and poorly correlated in space (nonsmooth Kraichnan noise). The associated linear transpo...

In the recent resolution of the strong Onsager’s conjecture in L^3 framework, so-called wavelet-inspired Nash’s iteration has been developed. In this lecture, we will sketch this new method and provide the necessary background. The lecture will be based on our recent joint work with Matthew Novack.

There is a well-known discrepancy in mathematical fluid mechanics between phenomena that we can observe and phenomena on which we have theorems. The challenge for the mathematician is then to formulate an existence theory of solutions to the equations of hydrodynamics which is able to reflect observation. The most important such observation, forming the backbone of turbulence theory, is anomalous dissipation. In the talk, we survey some of the recent developments concerning weak solutions in this context.

We start by demonstrating that numerical methods do not necessarily converge to entropy or admissible weak solutions of the Euler and Navier-Stokes equations of fluid dynamics on mesh refinement due to appearance of eddies at smaller and smaller scales. As an alternative, we revisit the concept of statistical solutions which are time-parametrized probability measures, consistent with the fluid evolution. We empirically show that the same numerical methods converge to a statistical solution and also derive verifiable sufficient conditions under which this convergence can be made rigorous. Numerical experiments illustrating interesting properties of statistical solutions are also presented. We conclude by showing how state of the art generative AI models (conditional diffusion) can significantly lower the cost of computing statistical solutions while maintaining accuracy.

Alterations in nuclear and chromatin organization are hallmarks of cellular aging and many aging related diseases including cancer and neurodegeneration. However, quantitative methods to analyse subtle alterations in chromatin states to understand cell-state transitions and for early disease diagnostics are still missing. In this talk, I will first describe our AI-based chromatin imaging biomarker platform. I will then demonstrate the sensitivity of this platform to trace tumour progression and neurodegeneration using tissue biopsies. Furthermore, I will describe our ongoing clinical trials, using AI-based chromatin biomarkers in blood biopsies, for early disease diagnostics and for tracing the efficacy of therapeutic interventions in personalized and precision medicine. Finally, I will introduce a major global public health project that we have initiated to develop a chromatin imaging atlas of human blood cells in health and disease.