ICTS:32864

Riboregulation: the story unfolds…

(2025). Riboregulation: the story unfolds…. SciVideos. https://scivideos.org/icts-tifr/32864

Riboregulation: the story unfolds…. SciVideos, Sep. 28, 2025, https://scivideos.org/icts-tifr/32864 

          @misc{ scivideos_ICTS:32864,
            doi = {},
            url = {https://scivideos.org/icts-tifr/32864},
            author = {},
            keywords = {},
            language = {en},
            title = {Riboregulation: the story unfolds{\textellipsis}},
            publisher = {},
            year = {2025},
            month = {sep},
            note = {ICTS:32864 see, \url{https://scivideos.org/icts-tifr/32864}}
          }
Matthias Hentze
Talk numberICTS:32864
Source RepositoryICTS-TIFR

Abstract

Following the discovery that the RNA-binding proteome is far larger than previously anticipated (Castello et al., 2012), riboregulation, the direct control of protein function by RNA, has begun to emerge as a new paradigm of biological control (Horos et al., 2019; Huppertz et al., 2022; Chatterjee et al., 2024; Hentze et al., 2025). We are beginning to understand molecular mechanisms of riboregulation, and I will discuss their implications for cell biology, metabolism and disease mechanisms as well as the new therapeutic opportunities. I will also share very recent unpublished data that add a new dimension to the concept of riboregulation…

Castello, A., B. Fischer, K. Schuschke, R. Horos, B.M. Beckmann, C. Strein, N.E. Davey, D.T. Humphreys, T. Preiss, L.M. Steinmetz, J. Krijgsveld and M.W. Hentze. Insights into RNA biology from an atlas of mammalian mRNA-
binding proteins. Cell 149, 1393-1406, 2012.

Hentze, M.W., P. Sommerkamp, V. Ravi and F. Gebauer, Rethinking RNA-binding proteins: riboregulation challenges prevailing views. Cell, in press, 2025.

Horos, R., M. Büscher, R. Kleinendorst, A.-M. Alleaume, A.K. Tarafder, T. Schwarzl, D. Dziuba, C. Tischer, E.M. Zielonka, A. Adak, A. Castello, W. Huber, C. Sachse and M.W. Hentze, The small non-coding vault RNA1-1 acts
as a riboregulator of autophagy. Cell 176, 1054-1067, 2019.

Huppertz, I., J.I. Perez-Perri, P. Mantas, T. Sekaran, T. Schwarzl, F. Russo, D. Ferring-Appel, L. Dimitrova-Paternoga, E. Kafkia, J. Hennig, P.A. Neveu, K. Patil and M.W. Hentze. Riboregulation of Enolase 1 Activity Controls
Glycolysis and Embryonic Stem Cell Differentiation. Mol. Cell 82, 2666-2680, 2022.

Chatterjee, A., M. Noble, T. Sekaran, V. Ravi, D. Ferring-Appel, T. Schwarzl, R. Rampelt and M.W. Hentze. RNA promotes mitochondrial import of F1-ATP synthase subunit alpha (ATP5A1). doi: https://doi.org/10.1101/2024.08.19.608659.