A short story on sibling rivalry among two chromatin organizer proteins
APA
(2024). A short story on sibling rivalry among two chromatin organizer proteins. SciVideos. https://youtube.com/live/CyJoODCQAEs
MLA
A short story on sibling rivalry among two chromatin organizer proteins. SciVideos, Sep. 16, 2024, https://youtube.com/live/CyJoODCQAEs
BibTex
@misc{ scivideos_ICTS:29626,
doi = {},
url = {https://youtube.com/live/CyJoODCQAEs},
author = {},
keywords = {},
language = {en},
title = {A short story on sibling rivalry among two chromatin organizer proteins},
publisher = {},
year = {2024},
month = {sep},
note = {ICTS:29626 see, \url{https://scivideos.org/icts-tifr/29626}}
}
Abstract
Chromatin is organized hierarchically at multiple scales and this is crucial for the spatiotemporal regulation of transcription. The fundamental units of nuclear organization are the highly self-interacting regions of chromatin termed as ‘Topologically Associated Domains’ or TADs. TADs are formed by a loop-extrusion mechanism mediated by two proteins: cohesin and CTCF. The major function of these units is to limit the action of regulatory elements to genes within the same TAD. Disruption of TAD boundaries can lead to dysregulation of gene expression and accessibility with a dramatic phenotypic consequence on developmental processes and pathogenesis Given the importance of CTCF in the formation of TADs and the role of the latter in gene regulation, it is not surprising that mutation in this protein have been reported in several diseases. While CTCF is a ubiquitously expressed, essential protein, it has a paralogue; CTCFL with a similar DNA binding domain that is normally expressed only ...