ICTS:29631

Video URL

Mechanism of Somatic Hypermutation in B cell immunity and lymphomagenesis

Mechanism of Somatic Hypermutation in B cell immunity and lymphomagenesis

(2024). Mechanism of Somatic Hypermutation in B cell immunity and lymphomagenesis. SciVideos. https://youtube.com/live/erGODsLQJQ0

Mechanism of Somatic Hypermutation in B cell immunity and lymphomagenesis. SciVideos, Sep. 16, 2024, https://youtube.com/live/erGODsLQJQ0 

          @misc{ scivideos_ICTS:29631,
            doi = {},
            url = {https://youtube.com/live/erGODsLQJQ0},
            author = {},
            keywords = {},
            language = {en},
            title = {Mechanism of Somatic Hypermutation in B cell immunity and lymphomagenesis},
            publisher = {},
            year = {2024},
            month = {sep},
            note = {ICTS:29631 see, \url{https://scivideos.org/icts-tifr/29631}}
          }
Uttiya Basu
Talk numberICTS:29631
Source RepositoryICTS-TIFR
Source EventInterdisciplinary aspects of chromatin organization and gene regulation
Collection

Abstract

B cells undergoing physiologically programmed or aberrant genomic alterations provide an opportune system to study the causes and consequences of genome mutagenesis. Activated B cells in germinal centers express activation-induced cytidine deaminase (AID) to accomplish physiological somatic hypermutation (SHM) of their antibody-encoding genes. In attempting to diversify their immunoglobulin (Ig) heavy- and light-chain genes, several B-cell clones successfully optimize their antigen-binding affinities. However, SHM can sometimes occur at non-Ig loci, causing genetic alternations that lay the foundation for lymphomagenesis, particularly diffuse large B-cell lymphoma. Thus, SHM acts as a double-edged sword, bestowing superb humoral immunity at the potential risk of initiating disease. We refer to off-target, non-Ig AID mutations - that are often but not always associated with disease - as aberrant SHM (aSHM). A key challenge in understanding SHM and aSHM is determining how AID targets and...