ICTS:32819

Small Molecule-mediated Modulation of RNA Conformations in Biotechnology and Therapeutics

(2025). Small Molecule-mediated Modulation of RNA Conformations in Biotechnology and Therapeutics. SciVideos. https://scivideos.org/icts-tifr/32819

Small Molecule-mediated Modulation of RNA Conformations in Biotechnology and Therapeutics. SciVideos, Sep. 21, 2025, https://scivideos.org/icts-tifr/32819 

          @misc{ scivideos_ICTS:32819,
            doi = {},
            url = {https://scivideos.org/icts-tifr/32819},
            author = {},
            keywords = {},
            language = {en},
            title = {Small Molecule-mediated Modulation of RNA Conformations in Biotechnology and Therapeutics},
            publisher = {},
            year = {2025},
            month = {sep},
            note = {ICTS:32819 see, \url{https://scivideos.org/icts-tifr/32819}}
          }
Ambadas Rode
Talk numberICTS:32819
Source RepositoryICTS-TIFR

Abstract

Beyond the transfer of genetic information, RNA drives many cellular processes, e.g., transcription, splicing, translation, and its own stability, through its three-dimensional structures. The RNA molecules adopt simple secondary to complex tertiary structures using Watson-Crick base-pairing and tertiary interactions such as loops, bulges, helical junctions, and long-range interactions. The RNA secondary and tertiary structures are in equilibrium with competitive alternative conformations to form a different population of substructures. The different RNA substructures give rise to a distinct biological outcome and play a crucial role in human health and disease. The alternative RNA conformations equilibrium can be shifted in response to external cues such as small molecule ligands for therapeutic and biotechnological applications. Our group research focuses on modulating the nucleic acids structure- mediated gene regulation by small molecules in humans, bacteria and viruses for biomedical applications. In the talk, I will provide an overview of some of the alternate RNA conformations, e.g., G-quadruplex, riboswitches, etc., and the use of these structures for therapeutic and biotechnological applications.

References:
1. Ojha D, Rode AB*, Nature Communications (2025) 16(1):5751.
2. Gupta P., Khadake R.M., Singh O.N., Mirgane, H.A., Gupta, D., Bhosale S.V., Vrati, S., Surjit, M., Rode A. B.* ACS Infect. Dis. (2025), 11, 3,
784–795.
3. Khadake R.M., Arora V., Gupta P., Rode A. B.* ChemBioChem (2025), e202401015.
4. Gupta P, Khadake RM, Panja S, Shinde K, Rode AB* Genes, (2022), 13, 1930.
5. Pandey M, Ojha D, Bansal S, Rode AB*, Chawla G* Molecular Aspects of Medicine (2021), 81, 101003.