ICTS:29649

Video URL

AI-based Chromatin Imaging Biomarkers in Health and Disease

AI-based Chromatin Imaging Biomarkers in Health and Disease

(2024). AI-based Chromatin Imaging Biomarkers in Health and Disease. SciVideos. https://youtu.be/ZPN5Ujl_IY0

AI-based Chromatin Imaging Biomarkers in Health and Disease. SciVideos, Sep. 19, 2024, https://youtu.be/ZPN5Ujl_IY0 

          @misc{ scivideos_ICTS:29649,
            doi = {},
            url = {https://youtu.be/ZPN5Ujl_IY0},
            author = {},
            keywords = {},
            language = {en},
            title = {AI-based Chromatin Imaging Biomarkers in Health and Disease},
            publisher = {},
            year = {2024},
            month = {sep},
            note = {ICTS:29649 see, \url{https://scivideos.org/icts-tifr/29649}}
          }
G. V. Shivashankar
Talk numberICTS:29649
Source RepositoryICTS-TIFR
Source EventInterdisciplinary aspects of chromatin organization and gene regulation
Collection

Abstract

Alterations in nuclear and chromatin organization are hallmarks of cellular aging and many aging related diseases including cancer and neurodegeneration. However, quantitative methods to analyse subtle alterations in chromatin states to understand cell-state transitions and for early disease diagnostics are still missing. In this talk, I will first describe our AI-based chromatin imaging biomarker platform. I will then demonstrate the sensitivity of this platform to trace tumour progression and neurodegeneration using tissue biopsies. Furthermore, I will describe our ongoing clinical trials, using AI-based chromatin biomarkers in blood biopsies, for early disease diagnostics and for tracing the efficacy of therapeutic interventions in personalized and precision medicine. Finally, I will introduce a major global public health project that we have initiated to develop a chromatin imaging atlas of human blood cells in health and disease.