From the ominous conclusion “there is no treatment” mentioned in the ancient Egyptian Edwyn Smith papyrus, to a remarkable recent clinical trial on rectal cancer patients using dostarlimab – where all 12 enrolled patients achieved complete remission with no recurrence for up to 25 months of follow up, our understanding of cancer and its treatment has progressed immensely over the years. Yet, the majority of cancer types remain untreatable due to eventual development of drug resistance and metastasis, and newer approaches to understanding the fundamental principles of cancer are much needed. With the advent of advanced sequencing and imaging techniques and ever-increasing resolution and throughput of current experimental technologies, mathematical and computational approaches in cancer are now witnessing a revolution. There is a rapidly increasing effort to use theoretical tools as orthogonal approaches to understand and control the evolution of this disease. Recent mathematical modelin...
Description